| 摘要 |
Alkanolamines (I) where Y = O R1, R3, R4 = H (R2 = Et (B = 4-Cl-3-Me-phenyl; 3,5-Me2-phenyl (R2 = n-Pr (B = 3-tolyl; 3,5-Me2-phenyl; 2,5-Cl2-phenyl; 3-MeO-phenyl or Y = O R1 = H, opt. substd. alkyl, alkenyl, aralkyl R3, R4 = H, alkyl R2 = branched alkyl, substd. alkyl, cycloalkyl alkenyl, opt. substd. ( >7C) aralkyl B = phenyl substd. at 3 or 4 only, or is substd. at 2 only by: iodine, HO, NO2, acyl, aryl, aryloxy, alkylaryloxy, arylthio, arylsulphonyl, arylamino, aralkyl, aralkoxy; or it is substd. by up to 5 substituents, or Y = S R1 = H R3, R4 = H, alkyl R2 = H, alkyl, cycloalkyl, alkenyl, aralkyl B = substd. phenyl together with their esters and salts, but excluding the following 1-(substd. phenoxy)-3-(substd. amino)-2-propanols:- 1- 4-Cl 3- 1-Me-2-Ph-ethyl; cyclohexyl; isoamyl 2,6-Me2 isopropyl 4-t-amyl isobutyl; isoamyl; isopropyl 4-t-butyl isoamyl 2-MeO isobutyl; N-isopropyl-N-Me. beta-Adrenergic blockers, useful in the treatment of coronary arterial disease. A mixt. of 1-Cl-3-(2,3-Me2-phenoxy)-2-propanol (II) (2.03 pts.) and isopropylamine (15 pts.) is heated at 70-80 deg. for 10 hrs Working up gives 1-(2,3-Me2-phenoxy)-3-isopropylamino-2-propanol, m.p. 110-2 deg. (petrol). |
