| 摘要 |
Process for the prepn. of the title cpds. as follows: a 13 beta-alkyl-3-hydroxy (or protected hydroxy)-17 -ethyl -gona-1,3,5(10),9(11)-tetraen-17 -ol is hydroborated to the triene-11,17 -diol. Oxidising the 11-oxy product to 11-oxo, dehydrating the 17-hydroxy to the 17-ethylidene cpd., Birch reducing to give a 3-alkoxy-2, 5(10)-diene, hydrolysing this product to give a 5(10)-en-3-one or 4-en-3-one and oxidising gives the pentaoxy-genated deriv. The products have corticosteroid and hormonal properties and are steroid intermediates. A typical product is 13 beta-ethyl-11 alpha, 17 alpha, 21-trihydroxy-18,19-dinorpregn-4-ene-3,20-dione. |
