| 摘要 |
0691H/5009V 18370 TITLE OF THE INVENTION NEW METHOD FOR INHIBITING BONE RESORPTION Disclosed is a new method for treating bone disease in mammals, which is associated with increased bone resorption activity (dissolution or breakdown), and involves the new use and administration of known bone acidic glycoproteins 75 (BAG 75), having a molecular weight of 75kDa as determined by SDS-PAGE, or the 50kDa (SDS-PAGE) fragment thereof, wherein BAG 75 contains an N-terminal sequence of: , (SEQ. ID NO. 1), (LPVARYQNTEEEE). The method is applicable and indicated for osteoporosis, Paget's disease, hyperparathyroidism, hypercalcemia of malignancy, osteopenia due to bone metastases, bone loss due to immobilization, sex hormone deficiency, glucocorticoid treatment, periodontal disease, and periarticular erosion in rheumatoid arthritis.
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