| 摘要 |
PURPOSE:To provide a catalyst optimal for the rearrangement of an oxime to the corresponding amide in a liquid phase under mild conditions, prepared from an N,N-disubstituted formamide, chlorothiophosphoric diester and phosphorus oxytrichloride and/or phosphorus pentachloride. CONSTITUTION:In producing an amide by the rearrangement of the corresponding oxime, a catalyst prepared from (A) an N,N-disubstituted formamide of formula I (R1 and R2 are each 1-6C alkyl, 6-9C phenyl or substituted phenyl) (e.g. N,N-dimethylformamide), (B) a chlorothiophosphoric diester of formula II (R3 and R4 are each 1-8C alkyl, 6-9C phenyl or substituted phenyl) (e.g. dimethyl chlorothiophosphate) and (C) phosphorus oxytrichloride and/or phosphorus pentachloride, is used. For example, a mixture of a chlorothiophosphoric diester, phosphorus oxytrichloride or phosphorus pentachloride with an N,N- dialkylformamide is heated, if necessary, to prepared the present catalyst, which is then incorporated with an oxime to carry out rearrangement reaction. |
