NANOCRYSTALLINE MAGNETIC IRON OXIDE PARTICLES, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN MEDICAL DIAGNOSTICS AND THERAPY

摘要

Novel nanocrystalline magnetic particles are provided herein which consist o f a magnetic iron oxide core of Fe3 0 4, gamma-Fe2 0 3 or mixtures thereof, and an envelope chemisorbed to the core. The composition of the coating material comprises natural or synthetic glycosaminoglycans and/or their derivatives with molecular weights of 500 Da to 250,000 Da, if necessary, which have been covalently cross-linked with appropriate cross-linking agents and/or modified by specific additives. Processes for preparation of these particles as well as the use thereof in medical diagnostics and/or therapy are also taught.