发明名称 |
Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines |
摘要 |
4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon internal administration. The active ingredients are prepared by cyclizing N-(2-substituted benzyl)-1-(3,4-dimethoxyphenyl)-aminoethanol using either a Lewis acid or an acid cyclizing agent followed by demethylation at the 3,4-dimethoxyphenyl moiety.
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申请公布号 |
US4340600(A) |
申请公布日期 |
1982.07.20 |
申请号 |
US19800152252 |
申请日期 |
1980.05.22 |
申请人 |
SMITHKLINE CORPORATION |
发明人 |
BRENNER, L. MARTIN;WARDELL, JR., JOE R. |
分类号 |
A61K31/47;A61K31/472;A61P9/08;A61P13/02;A61P15/00;C07D217/16;(IPC1-7):A61K31/47 |
主分类号 |
A61K31/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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