7-OXABICYCLOHEPTYL SUBSTITUTED HETEROCYCLIC AMIDE PROSTAGLANDIN ANALOGS USEFUL IN THE TREATMENT OF THROMBOTIC AND VASOSPASTIC DISEASE

摘要

HA579 7-OXABICYCLOHEPTYL SUBSTITUTED HETEROCYCLIC AMIDE PROSTAGLANDIN ANALOGS USEFUL IN THE TREATMENT OF THROMBOTIC AND VASOSPASTIC DISEASE 7-Oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs are provided which are thromboxane A2 (TXA2) receptor antagonists or combined thromboxane A2 receptor antagonist/thromboxane synthetase inhibitors and have the structural formula wherein R is SO3H, P(O)OR3OH or P(O)R4OH, X is O or NH, and Z, R1, R2, R3 and R4 are as defined herein.