| 摘要 |
The solution concerns a method of production of (2S, 3S)-3-acetoxy-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepamine-4(5H)-on-hydrochloride of formula I, which has an antihypertensive effect and acts as calcium antagonist. It is used mainly for treatment of angina pectoris. The complicated production method is simplified by using, as initial material, lysine salts of (2S, 3S)-3-(2-aminophenylthio)-2-hydroxy-3-(4-methoxyphenyl)propionic acid, obtained by optical resolution of the relevant racemic acid in the form of centrifuged and non-dried cake. All the L-lysine is returned back to the technological process.<IMAGE>
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| 申请人 |
BELUSA JINDRICH ING.,CS;HRUSKOVA VERA RNDR.,CS;HAAS ZDENEK ING.,CS;KAMINSKA ZDENA,CS;PICHA FRANTISEK RNDR.,CS;DUSEK JIRI RNDR.,CS;TREFULKA MOJMIR ING.,CS;KYSILKA VLADIMIR RNDR. CSC.,CS;WOJNAR VLADIMIR ING.,CS;STUDENCIK ZDENEK RNDR.,CS;JELINEK JIRI ING.,CS |
发明人 |
BELUSA JINDRICH ING.,CS;HRUSKOVA VERA RNDR.,CS;HAAS ZDENEK ING.,CS;KAMINSKA ZDENA,CS;PICHA FRANTISEK RNDR.,CS;DUSEK JIRI RNDR.,CS;TREFULKA MOJMIR ING.,CS;KYSILKA VLADIMIR RNDR. CSC.,CS;WOJNAR VLADIMIR ING.,CS;STUDENCIK ZDENEK RNDR.,CS;JELINEK JIRI ING.,CS |
