| 摘要 |
The invention thus provides the compounds of general formula (I) and salts, solvates and pharmaceutically acceptable derivatives thereof, in which X<1> and X<2> represent CH or are different and represent CH or N; Y<1>, Y<2>, Y<3> and Y<4> represent CH, or Y<1> and Y<4> represent CH and Y<2> and Y<3> represent N, or Y<2> and Y<3> represent CH and Y<1> and Y<4> represent N, or three of Y<1> to Y<4> represent CH and the other represents N; Z<1> represents CH or N; Z<2> represents N or N<+>R<6>; R<1> represents a hydrogen atom or a hydroxyl, C1-4alkyl or 2,2,2-trifluoroethyl group; R<2> represents a hydrogen atom or, when both X<1> and X<2> represent CH, may also represent a fluorine, chlorine or bromine atom or a C1-4alkyl group; R<3> represents a hydrogen atom or, when both Y<1> and Y<2> represent CH, may also represent a fluorine, chlorine or bromine atom or a C1-4alkyl group; R<4> and R<5> each represent a hydrogen atom; or, when Z<1> represents CH and Z<2> represents N, R<4> may also represent C1-4alkyl; or, when both Z<1> and Z<2> both represent N, R<4> and R<5> may be the same or different, and represent hydrogen or C1-4alkyl; R<6> represents a C1-4alkyl group or phenylC1-3alkyl group; R<7> represents a hydrogen atom; a C1-4alkyl group; a naphthyl group; a thiophene group; an unsubstituted phenyl group; a phenyl group substituted by C1-4alkyl group, C1-4alkoxy, phenylC1-3alkoxy, OH, halogen (where halogen is fluorine, chlorine, bromine or iodine), CF3, unsubstituted phenyl, phenyl substituted by OH, pyridinyl, NR<8>R<9>, NHSO2R<8>, CONR<8>R<9> or CO2R<8>; a C1-4alkyl group substituted by one or more naphthyl, phenyl, OH or CO2R<8>; a C2-4alkenyl group substituted by one or more naphthyl, phenyl, OH or CO2R<8>; or a saturated or unsaturated C5-7cycloalkyl group; and R<8> and R<9>, which may be the same or different represent H or C1-4alkyl or, together with the nitrogen atom to which they are attached, form a saturated 5 to 7 membered ring. |
