| 摘要 |
<p>Compounds of formula R-A1-A2-X-A3 wherein R i H, a protecting group or optionally substituted benzyloxy, A1 is an alpha -hdroxy or alpha -amino acid residue or a radical ( alpha ) as defined hereinafter, A2 is an alpha -hydroxy or alpha -amino acid residue or A1 and A2 form together a pseudo-dipeptide or a dipeptide mimetics residue or a radical (aa), (bb) or (cc) as defined hereinafter, X is a residue derived from Asp wherein A3 is -CH2 -X1-C0-Y1, -CH2-0-Y2, -CH2-S-Y3 or -CH2-(C0)m-Y6 wherein X1 is 0 or S, m is 0 or 1 and Y1, Y2, Y3 and Y6 are as defined herein after, have pharmacological activity, e.g. IL-1 beta release inhibiting properties.</p> |
