发明名称 |
TETRAHYDROPYRROLO[1,2-A]PYRAZINE-4-SPIRO-3'-PYRROLIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
摘要 |
The present invention is directed to tetrahydro- pyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives of the formula: wherein R1 and R2 are independently hydrogen, halogen, trifluoromethyl, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, or nitro, and R3 is hydrogen, halogen or alkyl having 1 to 6 carbon atoms, and pharama- ceutically acceptable salts thereof, processes for preparation thereof, and pharmaceutical compositions containing the same. Said compounds and their salts show excellent aldose reductase inhibitory activity and are useful for the prevention and treatment of diabetic complications.
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申请公布号 |
CA2071273(A1) |
申请公布日期 |
1992.12.27 |
申请号 |
CA19922071273 |
申请日期 |
1992.06.15 |
申请人 |
DAINIPPON PHARMACEUTICAL CO., LTD. |
发明人 |
NEGORO, TOSHIYUKI;MURATA, MAKOTO;UEDA, SHOZO;FUJITANI, BUICHI;ONO, YOSHIYUKI |
分类号 |
A61K31/495;A61P3/08;A61P3/10;C07D207/416;C07D487/20;C12N9/99;(IPC1-7):C07D487/20 |
主分类号 |
A61K31/495 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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