METODO PARA PRODUCIR ANTICUERPO MONOCLONAL HUMANO; METODO PARA LA PRODUCCION DE LINFOCITOS B HUMANOS PRODUCTORES DE ANTICUERPOS HUMANOS; COMPOSICION DE LINFOCITOS B INMORTALES; USO DE UN ANIMAL PARA PRODUCIR LINFOCITOS B INMORTALES; METODO PARA PRODU

摘要

The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.