Optical sensor for in vivo detection of analyte

摘要

A sensor for the in vivo detection of glucose comprises:;components of an assay for glucose, a readout of which is a detectable optical signal which can be interrogated transcutaneously by external optical means when the sensor is implanted in vivo; and;a shell of biodegradable material encapsulating the assay components while allowing analyte to contact the assay components, wherein the biodegradable material comprises a co-polymer having hydrophobic and hydrophilic units.;A method of preparing such a sensor preferably comprises coacervation, solvent evaporation and/or extraction, spray drying, spray coating, spray chilling, rotary disk atomisation, fluid bed coating, coextrusion and/or pan coating.;A method of detecting glucose using such a sensor suitably comprises implantation of the sensor into the skin of a mammal, transdermal detection or measurement of glucose using external optical means and degradation of the biodegradable material.

主权项

1. A sensor for the in vivo detection of glucose, comprising:
components of an assay for glucose, a readout of which is a detectable optical signal which can be interrogated transcutaneously by external optical means when the sensor is implanted in vivo; and a shell of biodegradable material encapsulating the assay components whilst allowing an analyte to contact the assay components, wherein the biodegradable material comprises a co-polymer having hydrophobic units and hydrophilic units, the hydrophilic units each comprising an ester of polyethylene glycol and a diacid.