| 发明名称 | Silicon dioxide nanoparticles and the use thereof for vaccination | ||
| 摘要 | The invention relates to ultrasmall, monodisperse nanoparticles comprising silicon dioxide to the surface of which at least one antigen is attached. The nanoparticles can be used for the immunoprophylaxis or immunotherapy of cancer. The invention also relates to a method for the targeting of antigens at antigen-presenting cells and for the activation of the immune system, where the efficiency of targeting and/or immunoactivation are set via the particle characteristics. The invention also relates to a method for the active and passive immunization of a mammal. | ||
| 申请公布号 | US9433673(B2) | 申请公布日期 | 2016.09.06 |
| 申请号 | US201514611891 | 申请日期 | 2015.02.02 |
| 申请人 | MERCK PATENT GMBH | 发明人 | Weigandt Markus;Hanefeld Andrea;Kuebelbeck Armin;Larbig Gregor |
| 分类号 | A61K39/39;A61K9/00;A61K9/51;A61K47/48;B82Y5/00;A61K39/00 | 主分类号 | A61K39/39 |
| 代理机构 | Millen, White, Zelano, Branigan, P.C. | 代理人 | Millen, White, Zelano, Branigan, P.C. |
| 主权项 | 1. A method for the activation of the immune system of a patient in need thereof and providing an adjuvant immune response, comprising parenterally administering to a patient in need thereof, monodisperse nanoparticles of silicon dioxide, where the nanoparticles have a diameter of 5 to 50 nm and are free of additional adjuvants. | ||
| 地址 | Darmstadt DE | ||