| 摘要 |
An insulin infusion device includes a processor architecture, and a memory element that stores executable instructions to perform a method of controlling delivery of insulin to a user. The method operates the device in a closed-loop mode to deliver insulin, obtains patient-specific parameters for a current time sample, and estimates a plasma insulin value and a blood glucose value for the user based on at least some of the patient-specific parameters. The estimating is also based on a previously estimated plasma insulin value obtained for a previous time sample, and a previously estimated blood glucose value obtained for the previous time sample. A predicted sensor glucose value is generated for the current time sample, and the closed-loop mode or a safe basal mode is selected for controlling operation of the insulin infusion device in accordance with the selected mode. |
| 主权项 |
1. An insulin infusion device comprising:
a reservoir for insulin to be delivered from the insulin infusion device to a body of a user; a processor architecture comprising at least one processor device; and at least one memory element associated with the processor architecture, the at least one memory element storing processor-executable instructions that, when executed by the processor architecture, perform a method of controlling delivery of insulin from the insulin reservoir to the body of the user, the method comprising:
automatically operating the insulin infusion device in a closed-loop mode to deliver insulin from the insulin reservoir to the body of the user;obtaining, for a current time sample, a patient-specific insulin gain value (KI), a patient-specific fasting insulin basal rate value (IBasal), a patient-specific fasting blood glucose value (SGBase), a meter blood glucose value (MBG), and an insulin delivered value (Iin) that represents an amount of insulin delivered since a preceding time sample;estimating, for the current time sample, an estimated plasma insulin value (Ipt) and an estimated blood glucose value (Gt) for the user, the estimating based on at least some of the values of KI, IBasal, SGBase, MBG, and (Iin), and the estimating further based on a previously estimated plasma insulin value obtained for a previous time sample (Ipt-1), and a previously estimated blood glucose value obtained for the previous time sample (Gt-1);generating, for the current time sample, a predicted sensor glucose value (SGp) for the user, the generating based on the values of Gt and SGBase for the current time sample;selecting either the closed-loop mode or a safe basal mode, based on at least some of the values of SGp, SG, Ipt, and Gt for the current time sample; andcontrolling operation of the insulin infusion device to deliver insulin to the body of the user in accordance with the selected mode. |
