| 摘要 |
1300419 Esters of 14-hydroxydihydronormorphinone derivatives ORGANON LABORATORIES Ltd 6 May 1970 [16 May 1969 17 April 1970] 25025/69 Heading C2C Novel 3 - alkoxy - N - substituted - 14 - acyloxy - dihydronormorphinones of the formula in which R is allyl, dimethylallyl, cyclopropylmethyl or cyclobutylmethyl, R 1 is a C 1-8 aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic carboxylic acyl group, and R 2 is a C 1-6 alkyl, or their acid addition salts, may be obtained by reacting the corresponding 14- hydroxy-dihydronormorphinone with a carboxylic acid R 1 OH or a functional derivative thereof, and optionally converting the product to an acid addition salt. Pharmaceutical compositions having analgetic, tranquillizing, cough suppressing and anticonvulsant properties comprise compounds of Formula I together with a pharmaceutical carrier in forms suitable for oral or parenteral administration. |
