Organische Thiazolopyrimidine

摘要

1285268 Thiazolopyrimidine derivatives BAXTER LABORATORIES Inc 29 July 1970 [13 Aug 1969] 36607/70 Heading C2C Novel thiazolopyrimidines of the Formula I wherein R is C 1 -C 4 alkyl or allyl may be prepared by (a) cyclizing a uracil thiourea of the Formula II using either hydrogen perioxide or bromine or (b) reacting 6-amino-1,3-dimethyluracil with an isothiocyanate RCNS in the presence of dimethylsulphoxide at reflux temperature. Pharmaceutical compositions of the compound I with the usual excipients show central nervous system anti-depressant activity when administered orally or parenterally.