摘要 |
<p>4-Demethoxy-daunomycinone I: <CHEM> the known aglycone of 4-demethoxy-daunorubicin, is prepared by protecting the 13-keto group of 4-demethyldaunomycinone, sulfonylating the 4-hydroxy group, reacting the sulfonylated compound, in an appropriate reducing environment, with a catalytic amount of a transition metal complex, preferably palladium or nickel with 1,3 diphenylphosphinopropane or 1,1 min -bis (diphenylphosphino) ferrocene, and eliminating the 13-dioxolanyl group by treatment with trifluoroacetic acid.</p> |
申请人 |
FARMITALIA CARLO ERBA S.R.L., MAILAND/MILANO, IT |
发明人 |
CABRI, WALTER, I-20051 LIMBIATE(MI), IT;BERNARDINIS, SILVIA DE, I-20100 MILANO, IT;FRANCALANCI, FRANCO, I-28100 NOVARA, IT;PENCO, SERGIO, I-20100 MILANO, IT |