| 摘要 |
PURPOSE:To obtain a new compound, capable of suppressing liberation and/or biosynthesis of tachykinin and thereby suppressing action of the tachykinin and useful for treating diseases in which the action of the tachykinin deeply participates in their morbid states. CONSTITUTION:A cyclohexylalkylamide expressed by formula I (R<1> is H or 1-3C alkyl; ring A is a 5- to 7-membered heterocyclic ring group which may have 1 or 2 N atoms and further 1 O atom; R<2> is H, lower alkyl, lower aralkyl or lower alkoxycarbonyl; B is single bond or alkylene; X is methyl, lower alkoxy, cycloalkyl, substitutive phenyl, phenoxy or indolyl) or its salt, e.g. (+ or -)- trans-2-(2,4,5-trichlorophenoxy)-N-methyl-N-[2-(1-pyrrolidinyl)cyclohe xyl]acetamide. The above-mentioned compound is obtained by carrying out acid amidating reaction of an amine expressed by formula III with a carboxylic acid expressed by formula IV or its reactive derivative. |
