发明名称 Hypotensive imidazole derivatives
摘要 Novel imidazole derivatives of the formula: <IMAGE> wherein R1 is lower alkyl or, phenyl-C1-2alkyl which may be substituted with halogen or nitro; R2 is lower alkyl, cycloalkyl or, phenyl which may be substituted with halogen, lower alkyl, lower alkoxyl or di(lower alkyl)amino, one of R3 and R4 is of the formula: -(CH2)n-COR5 in the formula R5 is amino, lower alkoxyl or hydroxyl and n is integer of 0, 1 or 2, and the other is hydrogen or halogen; provided that R1 is lower alkyl or phenethyl when R3 is halogen, n is 1 and R5 is lower alkoxyl or hydroxyl, and their salts have hypotensive activity.
申请公布号 US4340598(A) 申请公布日期 1982.07.20
申请号 US19800204356 申请日期 1980.11.05
申请人 TAKEDA CHEMICAL INDUSTRIES, LTD. 发明人 FURUKAWA, YOSHIYASU;KISHIMOTO, SHOJI;NISHIKAWA, KOHEI
分类号 A61K31/415;A61P9/12;C07D233/54;C07D233/64;C07D233/68;C07D233/90;(IPC1-7):A61K31/41 主分类号 A61K31/415
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