RESOLUTION OF ALPHA-PROPIONIC ACIDS

摘要

A method of resolving d- and I-isomers of an alpha-arylpropionic acid, wherein the isomers are enantiomers. The method involves forming an ammonium salt of the a-arylpropionic acid, then dissolving in a solvent the ammonium salt, and a chiral agent capable of reacting with the ammonium salt of at least one of the isomers. The reaction product of the chiral agent and the ammonium salt of the one of the isomers can subsequently be purified, then separated into the chiral agent and the isomer.