New arylsulfonamides and analogs, are cannabinoid receptor agonists used e.g. for treating neurodegenerative diseases, pain, convulsions or bacterial or viral infections

摘要

Arylsulfonamides (and analogs) (I) are new. Arylsulfonamides and analogs of formula R1-A-D-E-G-L-R2 (I) and their salts are new. R1 = 4- or 7-indenyl or phenyl having a 5-membered saturated, partially unsaturated or aromatic heterocycle (containing 1 or 2 of S, N, O, NH and NR as heteroatoms) fused in the 2,3-position, where all rings are optionally substituted by a wide range of specific groups; R = 1-6C alkyl; A, E = direct bond or 1-4C alkylene; D = O, S(O)e or N(R19); e = 0-2; R19 = H, R or acyl; G = 6-10C arylene or 5-7 membered heteroarylene (containing 1-3 of S, N and/or O), optionally substituted by several specific groups; L = O, NH, -N(R30)-SO2-, -N(R29)-SO-, -N(R29)-SO2-N(R29)-, -N(R29)-CO-, -SO2-N(R29)-, -O-SO2-, -N(R29)-P(O)(OR29)- or -N(OH)-SO2- (all bonded to G at the left terminal); R29 = H or 1-4C alkyl; R30 = H, 1-4C alkyl or SO2R2; R2 = aryl or 5-7 membered saturated or aromatic heterocycle (containing 1-3 of S, N and/or O), optionally substituted by specific groups; 7,7-dimethyl-bicyclo (2,2,1) heptan-2-on-1-ylmethyl; morpholine; cycloalkyl; or 1-12C alkyl, 2-12C alkenyl or 2-12C alkynyl, all optionally substituted by specific groups; or -L-R2 = 1,1-dioxo-isothiazolidin-2-yl; provided that R1 is other than 4-isoindolyl (optionally N-substituted by R and optionally further substituted); unless specified otherwise alkyl moieties have 1-8C, acyl moieties 1-6C, cycloalkyl moieties 3-8C and aryl moieties 6-10C. Full definitions are given in the 'DEFINITIONS - Full Definitions' field. An Independent claim is included for the preparation of (I).