Adenoviral vectors for mutants of human interleukin 6 (hIL-6) with hIL-6 antagonist activity, pharmaceutical compositions therewith and their uses

摘要

The subject matter of the present invention are recombinant defective adenoviruses comprising a heterologous DNA sequence coding for a mutein having the activity of human Interleukin 6 (hIL-6) antagonists or superantagonist. Moreover, the invention refers to therapeutical uses thereof, in particular for preparing pharmaceutical compositions for treating and/or preventing pathologies caused by hIL-6 overproduction.