NOVEL SYNTHETIC ANTIMICROBIAL HINGE PEPTIDE DERIVED FROM RIBOSOMAL PROTEIN L1 OF HELICOBACTER PYLORI AND COMPOSITION THEREFROM

摘要

An antibiotic peptide, and a composition containing the antibacterial peptide are provided to improve antibacterial and fungicidal effects and to remove cytotoxicity. An antibiotic peptide has the folding structure by replacing the glutamic acid of the 9th amino acid of the peptide HPA3 having the amino acid sequence represented by the sequence number 2 with proline, and has the sequence represented by the sequence number 3. Preferably the hydrophobic and flexible regions of the antibiotic peptide is increased compared with the peptide having the amino acid sequence represented by the sequence number 2.