The present invention relates to a method for the treatment or prevention of atrial fibrillation and/or atrial flutter comprising coadministration of a synergistically therapeutic amount of dronedarone or a pharmaceutically acceptable salt or salts thereof and a synergistically therapeutic amount of ranolazine or a pharmaceutically acceptable salt or salts thereof. Also provided are methods for modulating ventricular and atrial rhythm and rate. This invention also relates to pharmaceutical formulations that are suitable for such combined administration.
申请公布号
HUE026916(T2)
申请公布日期
2016.08.29
申请号
HUE10798436
申请日期
2010.12.20
申请人
Gilead Sciences, Inc.
发明人
ANTZELEVITCH, Charles;BELARDINELLI, Luiz;BURASHNIKOV, Alexander;SHRYOCK, John;ZENG, Dewan