Prame derived peptides and immunogenic compositions comprising these

摘要

The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid sequence of the human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein and to its use as such or in a composition as a medicament for the treatment and/or prevention of cancer.

主权项

1. A method for the treatment of cancer in which the human PRAME protein is overexpressed, comprising administering to a subject in need thereof an immunogenic composition comprising peptides having a length between 33 and 35 contiguous amino acids from the amino acid sequence of human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein, and wherein the peptides are selected from the group consisting of SEQ ID Nos: 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 16, and 18.