| 摘要 |
Novel 3-oximido-gona-4,9,11-triene derivatives having the general formula <FORM:1048232/C2/1> (in which R2 represents a hydrocarbon radical having from 1-18 carbon atoms, R3 is a hydrogen atom or an alkyl group, and R4 represents the oxygen atom of a keto group = C = O or the grouping H-b -OH are obtained in a process in which a 17b -hydroxy-gona-4,9,11triene-3-one derivative having the general formula <FORM:1048232/C2/2> is reacted with hydroxylamine or an alkyl ether thereof to form the corresponding 3-oximido - 17b - hydroxy - gona - 4,9,11 - triene which may be subjected to oxidation brought about by reaction with a ketone whereby a double exchange of functions occurs with the formation of the corresponding 3-oximido-gona - 4,9,11 - triene - 17 - one. The hydroxylamine may be in the form of the hydrochloride and the oxidation may be effected with aluminium isopropylate in cyclohexanone. |
