CREATINE ANALOGS HAVING ANTIVIRAL ACTIVITY

摘要

The present invention relates to the use of creatine and suitable creatine analogs, such as cyclocreatine, as antiviral agents. These compounds can be used as antiviral agents against a variety of viruses, particularly DNA viruses, such as Herpes viruses (e.g., HSV-1, HSV-2, cytomegaloviruses, Varicella-Zoster virus) and adenovirus. The invention further relates to suitable creatine analogs having antiviral activity, including creatine analogs that can be phosphorylated by creatine kinase and the phosphorylated forms of the creatine analogs.