摘要 |
(1) Compounds of formula:- (I) X.CO- -Y-phenylene-SO2-NHCONHR' and their pharmaceutically acceptable salts where R = lower alkyl, lower phenylalkyl or H R' = dimethyl- or 4, 4-diethyl-cyclohexyl X is (a) phenyl, opt. substd. by Z and Z' where Z is H, halogen, lower alkyl, alkenyl, alkoxy, alkenoxy, halogenoalkoxy, alkoxyalkoxy, phenalkoxy or phenylalkyl, cycloalkoxy, phenyl, phenoxy, lower acyl, benzoyl, CF3, OH, lower acyloxy, CN, NO2 Z' is H, halogen, lower alkyl, alkoxy, alkoxyalkoxy, acyloxy or OH. (b) Naphthyl opt. substd. by one or two halogen, lower alkyl, alkoxy or OH (c) Tetrahydronaphthyl or indanyl (d) Thiophenyl, opt. substd. by one or two lower alkyl, phenylalkyl, alkoxy, alkoxyalkoxy, alkenoxy, phenalkoxy, aryl or halogen (e) Tetramethylene or trimethylenethenyl Y is a C1 to C3 hydrocarbon chain Blood sugar lowering agents useful in diabetis mellitus. |