发明名称 |
Method of inhibiting the activity of leukocyte derived cytokines |
摘要 |
A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula <IMAGE> (I) in which R1 and R2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. The inhibition of Il-1, TNF, and other cytokines in mammals is implicated in allerviation of a wide variety of disease conditions.
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申请公布号 |
US4965271(A) |
申请公布日期 |
1990.10.23 |
申请号 |
US19870131785 |
申请日期 |
1987.12.11 |
申请人 |
HOECHST ROUSSEL PHARMACEUTICALS, INC.;UNIVERSITY OF VIRGINIA |
发明人 |
MANDELL, GERALD L.;SULLIVAN, GAIL W.;NOVICK, WILLIAM J. |
分类号 |
C07D473/04;A61K31/52;A61K31/522;A61P29/00;A61P37/06;C07D473/06 |
主分类号 |
C07D473/04 |
代理机构 |
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地址 |
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