| 摘要 |
PURPOSE:To provide an intracorporeal self-retaining catheter which is not affected by pathogenic organisms over a long period of time immediately after retaining and does not cause inflammation through stimuli by fixing a cell adhesive protein to a preset position of the body retained portion of the medical catheter using a reagent having at least two reactive functional groups. CONSTITUTION:A cell adhesive protein is fixed using a reagent to a preset position of the body retained portion of a medical catheter which is retained in the body of a patient, the reagent having at least two reactive functional groups. As the reagent having at least two reactive functional groups, e.g. a polyaldehide, a polyisocyanate, an acid chloride or the like are employed, and as the cell adhesive protein e.g. fibrinogen, fibrin, fironectin, von Bill Brand factor, vitro nectin, collagen, laminin, gellatine or the like are employed. Thereby cells within subcutaneous tissue promptly adhere to the cell adhesive protein fixed layer and invasion of pathogenic organisms through the wall surface of the catheter can be prevented. |
