摘要 |
PURPOSE:To carry out growth and propagation of cells with sufficient gas supply without any trouble, by providing both culture medium feeding membranes and gas exchange membranes together in a bioreactor. CONSTITUTION:A bioreactor 14 is formed from many hollow fiber membranes constituting culture medium feeding membranes 8 and gas exchange membranes 9 in the interior of a cylindrical vessel 7. The inner surface of the cylindrical vessel 7 is closely adhered to the outer surface of the hollow fiber membranes with a bonding material 10, such as polyurethane resin, at both ends of the cylindrical vessel 7 to connect the interior of the hollow fiber membranes to a culture medium inlet pipe 2 or gas inlet pipe 1.
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