发明名称 |
INSULIN PRECURSORS, PROCESS FOR THEIR PREPARATION AND PROCESS FOR THE PREPARATION OF HUMAN INSULIN |
摘要 |
Novel human insulin precursors of the formula B-X-Y-A, wherein X and Y are each lysine or arginine, are prepared by culturing a yeast host transformed with a replicable expression vehicle capable of expressing a DNA-sequence encoding the human insulin precursors in yeast. Human insulin is prepared by recovery of the insulin precursors from the culture medium and converting the insulin precursors into human insulin by enzymatic treatment.
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申请公布号 |
CA1340823(C) |
申请公布日期 |
1999.11.16 |
申请号 |
CA19860504650 |
申请日期 |
1986.03.20 |
申请人 |
NOVO INDUSTRI A/S |
发明人 |
THIM, LARS;HANSEN, MOGENS TRIER;NORRIS, KJELD |
分类号 |
C07K14/575;A61K36/06;A61K38/28;C07H21/04;C07K1/20;C07K14/39;C07K14/62;C12N15/09;C12N15/81;C12P21/02;C12P21/04;C12R1/865;(IPC1-7):C12N15/17 |
主分类号 |
C07K14/575 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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