| 摘要 |
Benzoic acid derivatives represented by the formula (I): wherein R1 represents hydrogen or lower-alkyl, R2 and R4 represent hydrogen, trimethylsilyl, or trimethylgermyl, R3 represents hydrogen, lower-alkyl, trimethylsilyl, or trimethylgermyl, R5 represents hydrogen, lower-alkyl, acetyl, or hydroxy, at least one of R2 and R3 being trimethylsilyl or trinethylgermyl, and R6 means hydroxy, lower-alkoxy, or a group of the formula -NR7R8, wherein R7 and R8 mean hydrogen or lower-alkyl, and X represents a group of the formula -CONH-, -NHCO-, -COO-, -OCO-, -COCH=CH-, -COCH=C(OH), or -CH=CH-, which exhibit excellent effect as differentiation-inducing agents for neoplastic cells, especially leukemia cells, or a therapeutic agent for psoriasis or immune and inflammatory diseases, and a process for the preparation thereof, are disclosed.
|
