| 摘要 |
Furanone derivatives (II) and their salts are new : Furanone derivatives of formula (II) and their salts are new. [Image] R 1R', R'C(O), R'C(S), R'SO 2, R'OC(O) or R'NHC(O); R' : phenyl (substituted by R'') or a group of formula (a) - (c); X : O, S or NH; W, Y, Z : CH or N; R'' : H, 1-7C alkyl, 3-6C cycloalkyl, OH, SH, amino or halo; R 2, R 4H, 1-7C alkyl or 3-7C cycloalkyl; R 31-7C alkyl, 3-7C cycloalkyl or aryl-1-7C alkyl; R 51-7C alkyl, halo, aryl-1-7C alkyl, 1-3C alkylCONR''' or R iv; R iv(CH 2) nNR vR vi or a group of formula (d) - (g); R''' : not defined; n, m : 1-3; R v, R viH or 1-7C alkyl; A : N or CH; B : N, O, S or CH; R viiH or 1-7C alkyl when B = N or CH; or absent when B = O or S; R viiiO or 1-7C alkyl; R 6H, 1-7C alkyl, aryl-1-7C alkyl, 1-3C alkylSO 2R ix, 1-3C alkyl C(O)NHR ix or CH 2XAr. [Image] [Image] ACTIVITY : Immunosuppressive; antiinflammatory; antiarthritic; antirheumatic; antiallergic. MECHANISM OF ACTION : Cysteine protease cathepsin S inhibitor. |
