2-(SUBSTITUTED IMINO)-THIAZOLIDINES AND PROCESS FOR THE PREPARATION THEREOF

摘要

2-(Substituted imino)-thiazolidines and process for the preparation thereof The invention relates to new 2-(substituted imino)-thiazolidines, a process for the preparation thereof, pharmaceutical compositions comprising the same, the use of the said 2-(substituted imino) -thiazolidines for the treatment of diseases and for the preparation of pharmaceutical compositions suitable for the treatment of diseases. The new 2-(substituted imino)-thiazolidine derivatives provided by the present invention correspond to the general formula (I), (I) wherein R1 and R2 each represent halogen, nitro, C1-4 alkoxy or C1-4 alkyl, which latter may optionally carry one or more halogen substituent(s), R3 and R4 each represent hydrogen or C1-4 alkyl, Z denotes oxygen, sulfur or imino, which latter is substituted by a C1-6 alkyl or a C1-6 alkenyl group, R5 stands for hydrogen, C1-4 alkyl, C1-4 aikylthio or a group or the formula -NH-R, wherein R represents C1-6 alkyl, aryl, aralkyl or C1-6 alkenyl optionally carrying a halogen or a di-(C1-4 alkyl)-amino substituent; or Z and R5 together stand for a trivalent nitrogen atom, with the proviso that if Z denotes a substituted imino group, R5 stands for C1-4 alkylthio, and if R5 is C1-4 alkylthio, Z represents a substituted imino, and with the further proviso that if Z denotes sulfur, R5 is other than hydrogen or C1-4 alkyl, and possess valuable antianginal and analgesic properties.