摘要 |
Quinolone- and naphthyridone-carboxylic acid derivs. of formula (I) and their hydrates, addn. salts and (in the case of carboxylic acids) alkali and alkaline earth metal, Ag and guanidinium salts are new. In (I) X1 = H; Hal, NH2 or CH3; A = CH; CF; CCl; COCH3; CCH3; or N; and R1 = 1-3C alkyl; FCH2CH2-; cyclopropyl; or phenyl opt. mono- di- or tri-substd. by halo; or A + R1 = C-O-CH2-CH(CH3)-; R2 = H; 1-3C alkyl (opt. substd. by OH, hal or NH2; or 5-methyl-2-oxo-1,3-dioxol-4-ylmethyl; B = a gp. of formula (a) or (b); and (b) has the S,S, R,R, R,S or S,R configuration. In the formula, Y = O, or CH2; R3 = 2-5C oxoalkyl; -CH2-CO-C6H5; CH2CH2COR'; -C(CO2R')=CH-CO2R'; -CH=CH-COR'; or -CH2CH2CN; R4 = H, 1-3C alkyl; 5-methyl-2-oxo-1,3-dioxol-4-ylmethyl; or R3; R' = H or 1-3C alkyl.
|
申请人 |
BAYER AG, 51373 LEVERKUSEN, DE |
发明人 |
PETERSEN, UWE, DR., 5090 LEVERKUSEN, DE;KREBS, ANDREAS, DR., 5068 ODENTHAL, DE;SCHENKE, THOMAS, DR., 5060 BERGISCH GLADBACH, DE;PHILIPPS, THOMAS, DR., 5000 KOELN, DE;GROHE, KLAUS, DR., 5068 ODENTHAL, DE;BREMM, KLAUS-DIETER, DR., 5600 WUPPERTAL, DE;ENDERMANN, RAINER, DR., 5600 WUPPERTAL, DE;METZGER, KARL GEORG, DR., 5600 WUPPERTAL, DE;HALLER, INGO, DR., 5600 WUPPERTAL, DE |