发明名称 Oxygen sensors
摘要 Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.
申请公布号 US9375494(B2) 申请公布日期 2016.06.28
申请号 US201414209252 申请日期 2014.03.13
申请人 PROFUSA, INC. 发明人 Gamsey Soya;Wisniewski Natalie;Helton Kristen;McMillan William
分类号 A61K49/00;A61B5/00 主分类号 A61K49/00
代理机构 Cooley LLP 代理人 Cooley LLP
主权项 1. A sensor for detecting an analyte comprising a polymer, wherein said polymer comprises one or more residues of a luminescent dye, and wherein the luminescent dye is a photostable porphyrin dye and has excitation and emission spectra in the NIR optical window of a mammalian skin wherein the luminescent dye is a compound having formula:wherein M is H, Pd, Zn, Pt, Gd or Yb; each R1 is same or different and, independently, C(O)X—(CH2)n—YC(O)C(R4)CH2 or C(O)X—(CH2CH2O)mCH2CH2—YC(O)C(R4)CH2; R2 is C(O)X—(CH2)n—YC(O)C(R4)CH2, C(O)X—(CH2CH2O)mCH2CH2—YC(O)C(R4)CH2; R2 and R3 are fused, in each case, to form a cycloalkenyl, aryl, or heteroaryl group; X is O or NR5; Y is O; R5 and R4 are independently H or C1-C4 alkyl; each R6 is same or different and, independently, H or F; n is 1-10; and m is 1-300.
地址 South San Francisco CA US