Zwitterionic polymers with therapeutic moieties

摘要

The invention generally relates to zwitterionic polymers (including zwitterionic copolymers), such as polymethacrylic structures, with pendent functional moieties, such as therapeutic or biologic moieties. More particularly, the invention relates to phosphorylcholine-substituted methacrylic polymers prepared by free radical polymerization and click chemistry, for example, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as biological or therapeutic agents and in drug delivery thereof.

主权项

1. A co-polymer comprising the structure of: wherein each of R1 and R3 is independently a hydrogen, alkyl, or halogen; each of R2 and R4 is independently a hydrogen, (C1-C15) alkyl, (C1-C15) alkyloxy, or halogen; RZ is a group comprising a zwitterionic moiety; m is an integer from 1 to about 500; n is an integer from 1 to about 100; Lq is a linking group; RX is a group comprising an azide or a carbon-carbon triple bond; LT is a linking group; T is a targeting moiety towards a biological target; and wherein T is selected from the group consisting of an antibody, protein, aptamer, or a small molecule comprising a folate moiety.