Risperidone-containing implants and methods of use thereof

摘要

The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.

主权项

1. A method for treating schizophrenia in a subject in need thereof, the method comprising: administering to said subject a controlled release composition for providing an implant, said composition comprising a therapeutic drug and a polymer, said polymer comprising polylactic acid (PLA) and optionally polyglycolic acid (PGA) in a PLA:PGA molar ratio between 50:50 and 100:0, wherein said therapeutic drug is present in an amount of about 10%-60% of the mass of said composition, wherein the presence of said polymer in said composition extends the release duration of said therapeutic drug in a subject, and wherein said therapeutic drug is risperidone or 9-OH-risperidone, thereby treating said schizophrenia in said subject.