DEFECTIVE PACKAGING NON-ONCOVIRAL VECTORS BASED ON MPMV AND HIV

摘要

The present invention relates to vectors and their use in gene transfer, In particular the invention provides a vector comprising nucleotides corresponding to the packaging nucleotides of a lentivirus, a heterologous gene, and, flanking the packaging nucleotide and the heterologous gene, sequences corresponding to those within and near the sufficient lentivirus LTR, for packaging, reverse transcription and integration of the vector into target cells and expression of the heterologous gene wherein said nucleotides comprise those corresponding at least substantially to the lentivirus 5' leader sequence and REV-responsive region.