发明名称 |
PEPTIDES USEFUL FOR INDUCING TOLERANCE |
摘要 |
The present invention is based on the discovery that subcutaneous administration of a peptide comprising at least one T cell epitope of a protein allergen or other protein antigen results in T cell tolerance upon subsequent exposure to the allergen or other antigen. Peptides useful for inducing tolerance in a mammal, such as a human by subcutaneous administration or other routes of administration are within the scope of this invention. Such peptides include peptide X (SEQ ID NO: 7), peptide Y (SEQ ID NO: 8), peptide Z (SEQ ID NO: 9), peptide A (SEQ ID NO: 10), peptide B (SEQ ID NO: 11), peptide C (SEQ ID NO: 12), peptide D (SEQ ID NO: 13), and peptide E (SEQ ID NO: 14), each as shown in the figure. It is preferred that such peptides be administered in soluble form. |
申请公布号 |
WO9319178(A3) |
申请公布日期 |
1993.11.25 |
申请号 |
WO1993US02462 |
申请日期 |
1993.03.25 |
申请人 |
IMMUNOLOGIC PHARMACEUTICAL CORPORATION |
发明人 |
GEFTER, MALCOLM, L.;GARMAN, RICHARD, D.;GREENSTEIN, JULIA, L.;KUO, MEI-CHANG;BRINER, THOMAS, J.;MORVILLE, MALCOLM |
分类号 |
C12N15/09;A61K38/00;A61K39/00;A61K39/35;A61P37/08;C07K7/08;C07K14/47;C07K16/18;C12N15/12;C12N15/62;C12P21/02;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|