| 摘要 |
1,126,672. Sulphamoylanthranilic hydroxylamides. FARBWERKE HOECHST A.G. 6 Dec., 1965 [8 Dec., 1964], No. 51658/65. Heading C2C. Novel compounds of the formula wherein R<SP>1</SP> is a benzyl, furfuryl or thenyl-(2) group, R<SP>2</SP> is a hydrogen or C 1-3 alkyl, R<SP>3</SP> is hydrogen or methoxy and X is Cl or Br are made either by reacting an appropriate 2,4-dihalo-5-sulphamoyl-benzoic hydroxylamide with an amine R<SP>1</SP>NH 2 , or by reacting a reactive derivative of a 4-halo-5-sulphamoyl-anthranilic acid, such as a halide or a symmetrical or mixed anhydride, with a hydroxylamine compound R<SP>2</SP>ONH 2 . 2,4 - Dihalo - 5 - sulphamoyl - benzoic hydroxylamide starting materials are made by treating the corresponding 2,4-dihalo-5-sulphamoyl-benzoic acid with thionyl chloride and reacting the resulting acid chloride with an amine R<SP>2</SP>ONH 2 . 4 - Halo - 5 - sulphamoyl - anthranilic acid halides and anhydrides are prepared from the free acid by standard methods for preparing acid halides and anhydrides. Pharmaceutical preparations having diuretic and saliuretic activity comprise the above compounds of the invention and a carrier, preferably in forms adapted to oral or parenteral administration. |
