| 摘要 |
<p>PURPOSE:To obtain the titled compound useful as an intermediate for pharmaceuticals, economically on an industrial scale in high yield, by using a relatively easily available dihydroxyacetone dimer as a raw material and catalytically reducing the material and NH3 with H2 in a solvent in the presence of a hydrogenation catalyst. CONSTITUTION:The objective compound can be produced at a yield of as high as 81-86% by (1) dissolving 1pt.wt. of dihydroxyacetone dimer of formula in preferably 1-5pts.wt. of water or an organic solvent and (2) subjecting the solution to catalytic reduction and hydrogenation with H2 in the presence of 2-10mol of NH3 (based on 1mol of the compound of formula) and 5-30wt% hydrogenation catalyst such as Raney Ni (based on the compound of formula) at 60-100 deg.C practically under 20-40kg/cm<2> pressure for 1-5hr. EFFECT:The objective compound having high purity can be produced using small amounts of solvent, catalyst and NH3 with simple distillation process without producing impurities having close boiling point to the objective compound. USE:Raw material for especially an X-ray contrasting medium.</p> |
