发明名称 |
Methods employing bacterial toxin-antitoxin systems for killing eukaryotic cells |
摘要 |
A method of inhibiting cell proliferation and/or cell cycle progression, the method comprising providing within eukaryotic cells a bacterial toxin, in particular a bacterial toxin of a post-segregational killing system such as <i>ParD</i>. Activity or production of toxin and/or inhibitor, e.g. antidote, are controlled for selective killing of target cells, not-target cells. Target cells include tumour cells. |
申请公布号 |
AU6000700(A) |
申请公布日期 |
2001.02.05 |
申请号 |
AU20000060007 |
申请日期 |
2000.07.17 |
申请人 |
CANCER RESEARCH VENTURES LIMITED |
发明人 |
GUILLERMO DE LA CUEVA MENDEZ;RONALD ALFRED LASKEY;ANTHONY DAVID MILLS;RAMON DIAZ OREJAS |
分类号 |
A61K38/16;A61K48/00;A61P35/00 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|