Compuestos derivados de pirazolo-piramidina, inhibidores selectivos de actividad fosfatidil-inositol-4-kinasa iii beta (pi4kiiib); composicion farmaceutica; y su uso para el tratamiento o prevencion de un trastorno inflamatorio, autoinmune u oncologico, una enfermedad viral o malaria o rechazo a trasplante de organos o celulas

摘要

A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.