Process for preparing pan-CDK inhibitors of the formula (I), and intermediates in the preparation

摘要

The invention relates to a novel process for the preparation of pan-CDK inhibitors of the formula (I), and intermediates of the preparation.;

主权项

1. A process for the preparation of a compound of the general formula (I)in which
R4 is a C1-C6-alkyl group or a C3-C7-cycloalkyl ring,comprising:
cleaving of the protective groups of a benzenesulphonic acid salt of a doubly protected anilinopyrimidine of the formula (I-8-R-BSA)by hydrogenation with palladium on activated carbon and hydrogen in methanol, and also by treatment with potassium carbonate in methanol to give a compound of formula (I).