Natural product antibiotics and analogs thereof

摘要

Provided herein are pure and isolated natural products and analogs thereof of Formula (I), (II), (III), and (IV), pharmaceutical compositions thereof, and methods of use, for example, for treating a bacterial infection. Further provided are methods useful in identifying an inhibitor of bacterial sugar fermentation in a bacterial strain, such as a compound (inhibitor) of Formula (I), (II), (III), or (IV):;
or a pharmaceutically acceptable salt thereof.

主权项

1. A method of treating a bacterial infection in a subject comprising administering an effective amount of a compound of Formula (I-b): or pharmaceutically acceptable salt thereof, to the subject; wherein:
each occurrence of RA, RB, and RC is hydrogen;R3 is unsubstituted C2-C10alkyl,wherein the bacterial infection is an Escherichia coli, Pseudomonas aeruginosa, Vibrio cholerae, methicillin-resistant Staphylococcus aureus, or Mycobacterium tuberculosis infection.