Synergistic biomolecule-polymer conjugates

摘要

The synergistic biomolecule-polymer conjugates are the long-acting, in vivo controlled continuous-release and hybrid synergy systems of biomolecules that provide increased biological activities and enhanced pharmacological properties for achieving greater therapeutic efficacies.

主权项

1. A synergistic biomolecule-polymer conjugate comprising the formula:
[(P-L)n-R—C]x-Mwherein M is a biologically active biomolecule; wherein x is the number of cleavable-linkage polymers coupled to said biomolecule and x≧1; wherein n≧2; wherein P is a polymer or polymer lipid; wherein Pn are multiple polymeric arms or pieces wherein their types and sizes may be the same or different; wherein Ln is a functional linkage moiety comprising at least one cleavable linkage and at least one permanent linkage; or Ln are all cleavable linkages; wherein R is a non-cleavable spacer connected between polymer and the biomolecule; and C is a coupling group attached to the biomolecule, wherein said synergistic biomolecule-polymer conjugate is cleaved in human blood plasma so that biologically active cleavage products are released.