Bioactive carbon nanotube composite functionalized with B-sheet polypeptide block copolymer, and preparation method thereof

摘要

The present invention relates to a bioactive carbon nanotube composite functionalized with a β-sheet polypeptide block copolymer by combination self-assembly, which shows excellent water dispersion, and has biological activity so as to be used as stimulus-responsive and adaptable biomaterials or in the manufacture of CNT-based electronic biosensor devices. In addition, the bioactive carbon nanotube composite can be used as a composition for delivery of a biological active material into cells. Further, the application of the interaction between a β-sheet peptide and a carbon-based hydrophobic material is expected to be useful for designing and developing an inhibitor for diseases caused by the abnormal folding of a protein and by biomacromolecular interactions (protein-protein, protein-DNA, and protein-RNA interactions etc).

主权项

1. A hybrid of β-sheet block copolypeptides and carbon nanotubes
wherein each (β-sheet block copolypeptide consists of a β-sheet polypeptide block and a bioactive polypeptide block, the β-sheet polypeptide block has an alternating series of nonpolar amino acids and polar amino acids or contains 50 to 100% of nonpolar amino acids, the bioactive polypeptide block consists of polar amino acids accounting for 50-100% of the total amino acids thereof, the β-sheet polypeptide block is non-covalently bound to the surface of the carbon nanotubes, and the bioactive polypeptide block is charged and exposed outside the hybrid; wherein the amino acids are the L-isomer form.